Brazil defender Marquinhos and former Inter striker Icardi were among seven PSG players to test positive for coronavirus earlier in September.
The list also included Neymar, Keylor Navas, Leandro Paredes, Angel Di Maria and Kylian Mbappe.
Mbappe, Marquinhos and Icardi were the only ones not given the green light to feature against Marseille on Sunday, though the remaining quartet could not help Thomas Tuchel’s side avoid a 1-0 defeat and their second loss of the Ligue 1 season in an ill-tempered Classique.
Neymar was shown a red card in a stoppage-time fracas – later claiming he was racially abused by Marseille’s Alvaro, allegations that the defender denied – with Paredes and Layvin Kurzawa also receiving their marching orders.
While Neymar, Paredes and Kurzawa will be missing on Wednesday, Tuchel has been handed a boost with the return of both Marquinhos and Icardi, with only Mbappe still in quarantine.
Marco Verratti and new signing Alessandro Florenzi both started against Marseille, though the Italy duo have not been included in Tuchel’s 21-man squad to face Metz.
Goalkeeper Navas did not make the bench on Sunday, though could be set to replace Sergio Rico, who has signed permanently from Sevilla following a successful loan spell.
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