The former world number one had accepted a wildcard to play in the Florida event, which would have represented his first tournament of 2021.
Murray, has now pulled out of the event but the 33-year-old Scot – who has well-documented hip injuries – is not thought to have made his decision based on fitness concerns.
Instead, the ongoing global health pandemic forced Murray into a rethink over his plans with the Australian Open on the horizon.
A widely released statement from the three-time grand slam winner read: “After much deliberation with my team I’ve decided not to travel to play in Delray Beach.
“Given the increase in COVID-19 rates and the transatlantic flights involved, I want to minimise the risks ahead of the Australian Open.
“I’m really thankful for the understanding of the tournament and I look forward to playing there soon.”
Murray has been handed a wildcard for the Australian Open, where he is a five-time finalist but has never won the tournament.
The season-open grand slam was pushed back to February 8 to allow players time a 14-day quarantine period upon arrival in Melbourne.
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